होम Regulatory Peptides The effect of guar supplementation on gastrin, motilin and GIP secretion following a high protein...
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78 THE EFFECT OF GUAR SUPPLEMENTATION ON GASTRIN, MOTILIN AND GIP SECRETION FOLLOWING A HIGH PROTEIN MEAL L. Morgan, J. Tredger, 3. Wright, P. Kwasowski and V. Marks, Division o f Clinical Biochemistry, Department of Biochemistry, University of Surrey, Guildford, U.K. Addition of the unabsorbable carbohydrate guar gum to a meal has been shown to delay gastric emptying and increase mouth-to-caecum transit time. The following study was undertaken to ascertain whether these effects were associated with altered patterns of GI hormone secretion. A f t e r a 12 h fast, 6 healthy non-obese volunteers were given a meal of 150 g lean minced beef, providing 50 g protein and 7 g fat, either with or without 5 g guar, incorporated into the meat. 1.5 g paracetamol was consumed simultaneously on each occasion with 300 ml water, as an index of gastric emptying. Blood was collected at intervals for 120 rain following the meal. Plasma paracetamol levels were unaffected by addition of guar to the meal. Postprandial gastrin secretion was significantly enhanced by the addition of guar. (Area under plasma gastrin curve 0-120 rain increased by 61 + 14%, p <0.005). Plasma m o t i l i n levels rose, but without significant difference between control and guar meals (basal levels 108 _+ 18 ng/l; peak levels for control and guar meals 155 + 37 ng/ml and 140 + 22 ng/ml respectively). Plasma GIP levels were significantly diminished by addition of guar. (Peak plasma GIP 954 + 173 ng/l vs. 599 + 87 ng/l, p <0.05; area under curve 0-120 rain decreased by 27 _+-4%, p <0.05). The-enhancement of gastrin secretion by guar was apparently not caused by differences in rates of gastric emptying, as estimated by paracetamol levels. GIP can stimulate gastric somatostatin release. The increased gastrin secretion could, therefore, be due to diminished post-prandial GIP secretion following guar. Alternatively, the augmented gastrin secretion may have been due to a reduction in the negative feedback e f f e c t of gastric acid resulting from t; he buffering capacity of guar. EFFECT OF SOMATOSTATIN ON INTESTINAL FUNCTION. A. Mitchell, J. Collin. (Nuffleld Department of Surgery, Oxford.) In 3 dogs a segment of jejunum was isolated with proximal and distal stomata on the abdominal wall. Electrodes were sutured to the serosal surface of the segment. The dogs were fed before each experiment a n d a solution containing 90 mmol/L NaCl and 100 mmol/L glucose was infused at 2.9 mls/min into the proximal stoma. Effluent was collected from the distal stoma for 3 hours. During the second hour somatostatin 2.5 ~gm/Kg./h. was continuously infused intravenously. Effluent volumes were measured and their sodium and glucose concentrations estimated. Electrical recordings were made from the jejunum throughout the experiment. Six experiments were performed on each dog. Compared with the control period somatostatin produced an immediate fall in volume output (5.5 ~ 0.33 to 2.]27 ~ 0.91;mean Z s.e.m, mls/5 mins) [ p<O.O01 ]. Total output of glucose and sodium were also significantly reduced$ Effluent glucose concentration rose (80 19 - 1 24 to 90 89 - 1.76 ;mean s.e.m, mmol/L) ~ p<O.O01 ] and sodlum concentratlon fell (99.58 1.11 to 93.5 Z 1.01 ;mean - s.e.m, mEq/L) [ p<O.OO1 ]. Mean transit time was prolonged (7.4 to 15.3 mins) [ p<0.O01 ]. Fast wave +electrical activity was significantly reduced (28 Z 1.4 to 1 1 Z 3.4 ;mean - s.e.m./5 mins) [ p<O.O1 ] but slow wave activity was unaffected by somatostatin. Somatostatin produces an apparent increase in intestinal absorption of water, glucose and sodium; reduces intestinal fast wave electrical activity and slows transit. + • " + • . " ÷